Effects of Corticosteroids on Cytosolic Free Calcium Concentration of the Rat Adrenal Zona Glomerulosa Cell

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Abstract
In the perfused cells isolated from the rat adrenal zona glomerulosa, deoxycorticosterone, aldosterone and dexamethasone (10 µM–1mM) significantly inhibited elevation of the cytosolic concentration of calcium ion [Ca2+]c caused by a preceding stimulation with angiotensin II (ANG II) or high K+. The inhibition of [Ca2+]c was observed within a few minutes after application of the corticosteroids. The resting level of [Ca2+]c was reduced by aldosterone, whereas it was not significantly altered by deoxycorticosterone or dexamethasone. Since it is well established that the elevation of [Ca2+]c is required for the secretory responses to ANG II or high K+, the present results are compatible with a view that aldosterone secretion from the cortical cells in response to the secretagogues may, in turn, be attenuated by corticosteroids, including aldosterone itself.

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