BRCA1 and cell signaling
- 11 December 2000
- journal article
- review article
- Published by Springer Nature in Oncogene
- Vol. 19 (53) , 6152-6158
- https://doi.org/10.1038/sj.onc.1203974
Abstract
The breast cancer and ovarian cancer susceptibility gene BRCA1 encodes a nucleoprotein whose mutations or aberrant expression is associated with both inherited and sporadic cancers. Studies over the last 6 years have suggested that BRCA1 may function as a scaffold in the assembly of a multi-protein complex, which plays a role in gene transcription, DNA damage repair, and transcription-coupled DNA damage repair. In this review, we discuss the implications drawn from the studies of BRCA1-interacting proteins and the cellular signaling pathways that may be involved in controlling the functions of BRCA1.Keywords
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