OBSERVATIONS ON THE APPLICATION OF THE ROBBINS‐MONRO PROCESS TO SEQUENTIAL TOXICITY ASSAYS
Open Access
- 1 April 1964
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology and Chemotherapy
- Vol. 22 (2) , 392-402
- https://doi.org/10.1111/j.1476-5381.1964.tb02044.x
Abstract
The Robbins‐Monro process is a sequential procedure which can be used in toxicity assays. The principal advantages are maximal economy of drug and animals and immediate availability of an estimate of the LD50 at any stage in the assay. The disadvantages are the need to wait for the outcome in each group of animals before testing the next group and the lack of an accurate method for determining confidence limits. Some practical details of the application of the method are given.Keywords
This publication has 10 references indexed in Scilit:
- Sequential Estimation of Quantal Response CurvesJournal of the Royal Statistical Society Series B: Statistical Methodology, 1963
- N-Alkyl Derivatives of VeratramineJournal of the American Chemical Society, 1960
- THE INFLUENCE OF ATROPINE ON THE TOXICITY OF THIALBARBITONE, THIOPENTONE AND PENTOBARBITAL1959
- On a Stochastic Approximation MethodThe Annals of Mathematical Statistics, 1954
- The Up-and-Down Method with Small SamplesJournal of the American Statistical Association, 1953
- The Up-and-Down Method with Small SamplesJournal of the American Statistical Association, 1953
- A Stochastic Approximation MethodThe Annals of Mathematical Statistics, 1951
- A SIMPLIFIED METHOD OF EVALUATING DOSE-EFFECT EXPERIMENTS1949
- A Method for Obtaining and Analyzing Sensitivity DataJournal of the American Statistical Association, 1948
- Biological AssayAnnual Review of Physiology, 1943