Radioresistance in some human tumor cells conferred in vitro by repair of potentially lethal X-ray damage.

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Abstract
In vitro X-ray survival curves were obtained from plateau-phase cultures of a human melanoma cell line [C-143] and a human breast cancer cell line [MCF-7]. After immediate subculture no radioresistance was seen in either cell line. After a 24-h delay in subculture the melanoma cell line developed significant radioresistance but the breast cancer cell line did not. The radioincurability of some melanomas may be due to radioresistance that occurs as a result of potentially lethal damage repair.