Capillary Electrophoretic Separation of Estrogens Using Anionic Sulfobutyl Ether β-Cyclodextrin

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Abstract
The determination of estrogens is important for the diagnosis of reproductive diseases and for monitoring the normal process of pregnancy. Previous separations of estrogens by capillary electrophoresis have employed a combination of cyclodextrins and surfactants. This paper describes the complete separation of five estrogens, 2-hydroxyestrone, 2-methoxyestradiol, estrone, estriol, and 17α-estradiol, using sulfobutyl ether β-cyclodextrin as the buffer additive. In this case, the separation can be accomplished with good efficiency without the addition of a surfactant or organic modifier to the run buffer.

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