Study of an inhibiting factor of epidermal proliferation in plucked skin and various tumours of mice

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Abstract
The aim of this research was to investigate, by autoradiographic methods, the presence of an inhibitory factor (IF) in normal skin, plucked skin and 5 experimental skin tumor of the mouse, capable of inhibiting epidermal proliferation. The experimental model used was that of Bullough and Laurence (1960), i.e., a wound in the ear of a mouse. After 3H-thymidine administration the measurement of the labeling index confirmed the existence of an inhibitory substance in normal skin. Plucked skin had no inhibitory effect when it was taken 24 h after plucking, but after 4 days its effect returned to normal. Skin tumors, whether epithelial or mesenchymal, showed the same inhibitory effect as normal skin whereas a noncutaneous tumor had no inhibitory effect.