Mouse mammary tumor virus integration regions int-1 and int-2 map on different mouse chromosomes.
Open Access
- 1 February 1984
- journal article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 4 (2) , 375-378
- https://doi.org/10.1128/mcb.4.2.375
Abstract
Two regions of mouse DNA which constitute common provirus integration sites in tumors induced by mouse mammary tumor virus have been identified and designated int-1 and int-2. By examining a series of hamster-mouse somatic cell hybrids, we mapped the int-2 locus to mouse chromosome 7 and confirmed the previous assignment of int-1 to chromosome 15. This constitutes proof that int-1 and int-2 are discrete genetic loci. It is therefore possible that proviral activation of two distinct cellular genes may result in the same neoplastic disease.Keywords
This publication has 19 references indexed in Scilit:
- Altered gene products are associated with activation of cellular rasK genes in human lung and colon carcinomasCell, 1983
- Onco gen: Human oncogene locations and chromosome aberrationsNature, 1983
- A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogeneNature, 1982
- Mechanism of activation of a human oncogeneNature, 1982
- Cellular Transforming GenesScience, 1982
- Use of transfection to analyze genetic information and malignant transformationBiochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1981
- Genetic mapping of the ecotropic virus-inducing locus Akv-2 of the AKR mouse.The Journal of Experimental Medicine, 1980
- Localization of a gene for expression of mouse mammary tumor virus antigens in the GR/Mtv-2- mouse strain.The Journal of Experimental Medicine, 1980
- Genetic Mapping of the Ecotropic Murine Leukemia Virus-Inducing Locus of BALB/c Mouse to Chromosome 5Science, 1979
- Integration of the DNA of mouse mammary tumor virus in virus-infected normal and neoplastic tissue of the mouseCell, 1979