THE EFFECT OF SEVEN VASOPRESSORS ON HALOTHANE MAC IN DOGS
Open Access
- 1 April 1975
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 47 (4) , 435-438
- https://doi.org/10.1093/bja/47.4.435
Abstract
SUMMARYWe evaluated the effects of ephedrine, mephentermine, metaraminol, phenylephrine, methoxamine, noradrenaline and adrenaline on halothane anaesthetic requirement (MAC) in dogs. MAC increased significantly only during ephedrine infusion (50%) although significance was approached with mephentermine (21%). Phenylephrine, metaraminol, methoxamine, noradrenaline and adrenaline did not change MAC. Arterial pressure was increased 50–100% with all agents. Our results support the hypothesis that anaesthetic requirement may be related, in part, to release of brain noradrenaline.Keywords
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