Coexistent neuroblastoma and Hirschsprung's disease ?Another manifestation of the neurocristopathy?
- 1 January 1979
- journal article
- Published by Springer Nature in Pediatric Radiology
- Vol. 8 (3) , 161-163
- https://doi.org/10.1007/bf00973826
Abstract
Abnormalities of neural crest development may be manifested in a wide variety of ways ranging from von Recklinghausen's disease to Sipple's syndrome — pheochromocytoma and medullary thyroid carcinoma. We report here yet another manifestation — coexistent multiple neuroblastomas and Hirschsprung's disease in a newborn. In a review of the English literature we have found the combination of neuroblastoma and Hirschsprung's disease recorded only once previously [2]. However, the relationship between the two diseases was not discussed. The two diseases may be at the extremes of a spectrum of neural crest developmental pathology, i. e., Hirschsprung's representing a deficiency and neuroblastoma representing malignant proliferation of cells of neural crest origin.Keywords
This publication has 2 references indexed in Scilit:
- The neurocristopathiesA unifying concept of disease arising in neural crest maldevelopmentHuman Pathology, 1974
- Familial NeuroblastomaNew England Journal of Medicine, 1967