Predicted protein sequence of the murine I-E-beta S-polypeptide chain from cDNA and genomic clones.
- 1 May 1985
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 82 (9) , 2910-2914
- https://doi.org/10.1073/pnas.82.9.2910
Abstract
Ia antigens are polymorphic cell-surface glycoprotein complexes, encoded within the I region of the mouse major histocompatibility complex, that control the ability of the organism to mount effective antigen-specific immune responses. The nucleotide sequences of c[complementary]DNA and genomic clones for the I-E.beta.s gene were isolated and determined and the predicted protein sequence for most of the E.beta.s polypeptide chain was presented. The E.beta.s polypeptide shows 95% protein homology to the other cloned E.beta. alleles. Comparison of the protein sequences of 5 E.beta. alleles from haplotypes that differ in responder phenotype to pigeon cytochrome c suggests that the structure of one of the E.beta. hypervariable regions may determine responsiveness to this antigen.This publication has 35 references indexed in Scilit:
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