Interactions among genes in the ErbB-Neuregulin signalling network are associated with increased susceptibility to schizophrenia
Open Access
- 1 January 2007
- journal article
- Published by Springer Nature in Behavioral and Brain Functions
- Vol. 3 (1) , 31
- https://doi.org/10.1186/1744-9081-3-31
Abstract
Evidence of genetic association between the NRG1 (Neuregulin-1) gene and schizophrenia is now well-documented. Furthermore, several recent reports suggest association between schizophrenia and single-nucleotide polymorphisms (SNPs) in ERBB4, one of the receptors for Neuregulin-1. In this study, we have extended the previously published associations by investigating the involvement of all eight genes from the ERBB and NRG families for association with schizophrenia.Keywords
This publication has 45 references indexed in Scilit:
- A haplotype map of the human genomeNature, 2005
- Developmental profile of ErbB receptors in murine central nervous system: Implications for functional interactionsJournal of Neuroscience Research, 2005
- Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergenceMolecular Psychiatry, 2004
- Multiple personalities of neuregulin gene family membersJournal of Comparative Neurology, 2004
- Neuregulin isoforms exhibit distinct patterns of ErbB family receptor activationOncogene, 2002
- Abnormal expression of epidermal growth factor and its receptor in the forebrain and serum of schizophrenic patientsMolecular Psychiatry, 2002
- A high-resolution recombination map of the human genomeNature Genetics, 2002
- ErbB4 and Its Isoforms Selective Regulation of Growth Factor Responses by Naturally Occurring Receptor VariantsTrends in Cardiovascular Medicine, 2000
- NEW EMBO MEMBERS' REVIEW: The ErbB signaling network: receptor heterodimerization in development and cancerThe EMBO Journal, 2000
- Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinaseOncogene, 1999