Clearances of plasma proteins from pulmonary vascular beds of adult dogs and pups

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Abstract
Clearances of plasma proteins from the pulmonary circulation were measured in 14 adult and 9 2-3-week-old dogs anesthetized with pentobarbital. Eleven of the adult dogs and all of the pups were maintained on intermittent positive-pressure ventilation. Rectal temperature and arterial pH, PO2, [O2 tension], and PCO2 [CO2 tension] were kept within normal limits. Pulmonary blood flow and mean transmural pulmonary artery wedge pressure (measured in dogs from which lymph was not collected) were similar for both age groups. Clearances of total protein, albumin, [alpha]-, [alpha]2, [beta]-+ [delta]-, and [gamma] -globulins (expressed as ml/100 g lung per hr) were 2-3 times greater for pups than for adult dogs. Comparison of the clearances of globulin fractions to clearance of albumin within each age group indicated that graded restriction to the passage of plasma proteins across the capillary wall occurs to a greater extent in mature than in immature dogs.