HETEROGENEITY AND SUBCOMPARTMENTALIZATION IN THE DISTRIBUTION OF EOSINOPHILS IN HUMAN COLONIC CARCINOMAS

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  • 1 January 1984
    • journal article
    • research article
    • Vol. 116  (2) , 207-213
Abstract
High concentrations of eosinophils in human colinic carcinomas are associated with better prognoses. Whether there were stromal subcompartments in these tumors with respect to the distribution of eosinophils was examined. Concentrations of eosinophils at the margin and deep to the margin were evaluated. For tumors with sufficient eosinophils to indicate good prognoses, the concentrations of eosinophils at the margins were strikingly lower than the concentrations in the samples remote from the margins. This is the 1st report that any kind of inflammatory cell is less concentrated in the periphery of a tumor than more centrally. When eosinophil concentrations were subjected to a square-root transformation, the transformed data for patients with and without metastases were different both for tumor from the margin (P = 0.001) and for tumor remote from the margin (P = 0.021).