A Spectrophotometric Method for the Estimation of Phenindione

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Abstract
A spectrophotometric method for the estimation of phenindione in pharmaceutical preparations and body fluids and tissues is described. It has a greater sensitivity than the existing British Pharmacopoeia method. Advantage has been taken of the solubility of the drug in toluene and the sensitivity of measurement has been found to be enhanced by the addition of alcoholic potassium hydroxide solution. This method accurately estimates 1–2 mg. of the substance as opposed to the 300 mg. required for the B.P. method. Further, as little as 2.5 μg./ml. of the substance can be detected in biological fluids after eliminating interfering substances.

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