First Synthesis of 10α-(Trifluoromethyl)deoxoartemisinin
- 7 February 2002
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 4 (5) , 757-759
- https://doi.org/10.1021/ol017227z
Abstract
A novel, nonacetal (trifluoromethyl)deoxoartemisinin was prepared with good stereoselectivity. This compound was obtained by debromination of the 10α-CF3-10-bromodeoxoartemisinin in the presence of tributyltin hydride at reflux in toluene without alteration of the endoperoxide bridge. It presented a reasonable antimalarial activity.Keywords
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