Conserved tyrosines in the alpha subunit of the nicotinic acetylcholine receptor stabilize quaternary ammonium groups of agonists and curariform antagonists.
Open Access
- 1 March 1994
- journal article
- Published by Elsevier in Journal of Biological Chemistry
- Vol. 269 (12) , 8808-8816
- https://doi.org/10.1016/s0021-9258(17)37041-2
Abstract
No abstract availableKeywords
This publication has 29 references indexed in Scilit:
- A molecular scheme for the reaction between acetylcholine and nicotinic channelsBiophysical Journal, 1993
- Functional significance of aromatic amino acids from three peptide loops of the α7 neuronal nicotinic receptor site investigated by site‐directed mutagenesisFEBS Letters, 1991
- Mutations affecting agonist sensitivity of the nicotinic acetylcholine receptorBiophysical Journal, 1991
- Mapping of the acetylcholine binding site of the nicotinic acetylcholine receptor: [3H]nicotine as an agonist photoaffinity labelBiochemistry, 1991
- Activation of Torpedo acetylcholine receptors expressed in mouse fibroblasts. Single channel current kinetics reveal distinct agonist binding affinities.The Journal of general physiology, 1990
- Direct measurement of the concentration- and time-dependent open probability of the nicotinic acetylcholine receptor channelBiophysical Journal, 1990
- Molecular basis of the two nonequivalent ligand binding sites of the muscle nicotinic acetylcholine receptorNeuron, 1989
- Amino acids of the Torpedo marmorata acetylcholine receptor .alpha. subunit labeled by a photoaffinity ligand for the acetylcholine binding siteBiochemistry, 1988
- Agonists block currents through acetylcholine receptor channelsBiophysical Journal, 1984
- Neuromuscular blocking agents: Structure and activityChemico-Biological Interactions, 1973