Quantitative Studies of Antigen Expression in Cultured Murine Lymphoma Cells. I. CellSurface Antigens in “Asynchronous” Cultures2

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Abstract
The relative amounts of H-2 and Moloney leukemia virusdetermined cell-surface antigens in intact, viable YAC lymphoma cells and cell homogenates were estimated by quantitative antibody absorption and inhibition of specific immune cytolysis. Antigenicity was inversely related to the growth rate of cells; the difference between the logarithmic-and the stationary-phase cells was approximately threefold when expressed per cell or per unit protein. The results are consistent with the postulate that the antigenic expression of cultured murine lymphoma cells is related to the position of the cells within the cell cycle and is maximal during the G1 period.

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