Treatment of Chronic Pain With Tricyclic Antidepressants

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Abstract
Tricyclic antidepressants (doxepin, imipramine, amitriptyline) are increasingly being used to treat chronic pain in humans. A review of the literature supports their use in a variety of conditions and sheds some light on the question as to whether they exert a direct analgesic effect or act indirectly, by first alleviating an intercurrent depression. Their use is recommended for chronic pain before resorting to narcotics or neurosurgery.

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