In-vitro interactions of DX-8739, a new carbapenem, meropenem and imipenem with amikacin against multiresistant Pseudomonas aeruginosa
Open Access
- 1 August 1996
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 38 (2) , 287-291
- https://doi.org/10.1093/jac/38.2.287
Abstract
In order to investigate the antimicrobial interactions against multiresistant Pseudomonas aeruginosa, thirty-seven strains resistant to antimicrobial agents of five different chemical classes were exposed in vitro to the combmation of three carbapenems, DX-8739, a novel DHP-1 stable analogue, meropenem and imipenem with amikacin. The tested combinations expressed an enhanced killing activity against 38–46% of strains and an additive effect against 5–13%. These effects were the same whether the applied carbapenem was DX-8739, meropenem or imipenem; they were also independent of the MIC of any antimicrobial.Keywords
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