Sequential Changes in Erythrocyte Volume Distribution and Microcytosis Associated with Iron Deficiency in Kittens
Open Access
- 1 January 1983
- journal article
- research article
- Published by SAGE Publications in Veterinary Pathology
- Vol. 20 (1) , 1-12
- https://doi.org/10.1177/030098588302000101
Abstract
Hemograms, erythrocyte volume distribution curves, serum iron and percent transferrin saturation determinations were done on samples from 50 kittens to characterize feline erythrocytic responses between one and ten weeks of age. At one week of age, all kittens had marked macrocytosis and anisocytosis. Most of the macrocytic cells no longer were present by five weeks. Macrocytes were replaced by erythrocytes of normal volume in 30% of the kittens. At five weeks of age, 70%of the kittens had produced microcytic cells which correlated with significantly lower packed cell volume values (p < 0.02) and mean corpuscular volume values (p < 0.001). By seven weeks of age, kittens with microcytosis were producing normocytic erythrocytes. Between two and four weeks of age, kittens with microcytosis had significantly lower serum iron and percent transferrin saturation values (p < 0.01) compared to kittens without microcytosis. Between five and seven weeks of age, all kittens had very high iron values which were significantly greater than those of healthy adult cats (p < 0.01). Six kittens with low iron values received an iron dextran injection at two to three weeks of age. At five weeks, these kittens had significantly greater mean corpuscular volumes, packed cell volumes (p < 0.01) and lower percentage of microcytic cells (p < 0.001) than littermate controls. These data demonstrate that transient microcytosis and anemia observed in kittens is attributable to iron deficiency. It also was demonstrated that erythrocyte volume distribution curves were more sensitive than the mean corpuscular volume in detecting microcytosis in kittens.Keywords
This publication has 20 references indexed in Scilit:
- Physiological anemia of early development in the rat: characterization of the iron-responsive componentThe American Journal of Clinical Nutrition, 1980
- Iron deficiency in infancy and childhoodThe American Journal of Clinical Nutrition, 1980
- The 'early anaemia'; its relation to postnatal growth rate, milk feeding, and iron availability. Experimental study in rabbits.Archives of Disease in Childhood, 1973
- Plasma Iron and Total Iron-Binding Capacity in Piglets in Anemia and Iron AdministrationJournal of Animal Science, 1972
- Contribution of Maternal Rat Iron Stores to Fetal Iron in Maternal Iron Deficiency and OverloadJournal of Nutrition, 1971
- Physiologic anemia of the newborn infantThe Journal of Pediatrics, 1971
- Abnormality of Red‐Cell Diameter/Thickness Ratio: Findings in Iron‐Deficiency AnaemiaBritish Journal of Haematology, 1970
- Ferrozine---a new spectrophotometric reagent for ironAnalytical Chemistry, 1970
- Effect of an injection of iron-dextran complex on blood constituents and bodyweight of young kidsPublished by Wiley ,1966
- The Requirement of the Baby Pig for Orally Administered IronJournal of Nutrition, 1960