Experimental Amyloidodis in Immunity

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Abstract
Mice exposed soon after birth to casein acquire an immune tolerance to this antigen. This was demonstrated by the absence of circulating antibodies as measured by the disappearance of casein-I131 from the circulation and by means of passive hemagglutination tests with ascitic fluids. Both, tolerant and control animals injected daily with casein developed amyloidosis to the same extent, thus ruling out classic immunological etiology as the basis of the disease However, the present results do not exclude the possibility of amyloidosis, being due to an auto-immune process.