Replacement of Virus-Destroyed Epithelium by Keratinized Squamous Cells in Vitamin A-Deprived Chickens

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Abstract
One localized area of nasal mucous membrane in chickens was selectively susceptible to initial infection with a myxovirus (NDV) and a giant-cell-forming herpesvirus (LTV). The same quite extensive mucosal area shows earliest signs of incipient keratinizing metaplasia in vitamin A-deprived chickens, and complete conversion to keratinized epithelium following NDV infection. Specific questions of interplay of A-deficiency and respiratory infection are open to study in this whole-animal model.

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