PROSTAGLANDINS RELEASE PLASMA ‘RECIPROCAL COUPLING FACTOR’ IN ANAESTHETIZED RATS
Open Access
- 1 October 1981
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 74 (2) , 485-487
- https://doi.org/10.1111/j.1476-5381.1981.tb09994.x
Abstract
Prostaglandins E1, E2, I2 and endoperoxide analogue U46619 injected intra‐arterially (i.a.) into anaesthetized rats at 2 μg/kg caused a substantial increase within 60 min of the plasma activity of prostaglandin ‘reciprocal coupling factor’ (RCF). RCF is the provisional name for the component(s) of plasma which inhibit microsomal prostaglandin synthesis and enhance cytosolic prostaglandin breakdown RCF is not released by inactive metabolite 13, 14‐dihydro‐15‐keto prostaglandin E2 (10 μg/kg, i.a.) or acetylcholine or histamine (2 μg/kg, i.a.) We suggest that release by prostaglandins of RCF could provide the basis in vivo for a negative feedback mechanism controlling the activity of the prostaglandin system.Keywords
This publication has 4 references indexed in Scilit:
- Human plasma contains prostaglandind ‘reciprocal coupling factor’European Journal of Pharmacology, 1980
- Pathophysiological states modify levels in rat plasma of factors which inhibit synthesis and enhance breakdown of PGNature, 1980
- Some biological effects of prostaglandin endoperoxide analogsLife Sciences, 1976