Antisense RNA to eIF4E Suppresses Oncogenic Properties of a Head and Neck Squamous Cell Carcinoma Cell Line
Open Access
- 1 June 2000
- journal article
- research article
- Published by Wiley in The Laryngoscope
- Vol. 110 (6) , 928-933
- https://doi.org/10.1097/00005537-200006000-00007
Abstract
Objective The translation initiation factor eIF4E is elevated in all head and neck squamous cell cancers (HNSCCs) and appears to be essential in the progression of solid tumors. Overexpression of eIF...Keywords
This publication has 13 references indexed in Scilit:
- Analysis of Surgical Margins With the Molecular Marker eIF4E: A Prognostic Factor in Patients With Head and Neck CancerJournal of Clinical Oncology, 1999
- Upregulation of protein synthesis initiation factor eIF-4E is an early event during colon carcinogenesisOncogene, 1999
- Detection of the Proto-oncogene eIF4E in Larynx and Hypopharynx CancersJAMA Otolaryngology–Head & Neck Surgery, 1999
- eIF4E expression in tumors: its possible role in progression of malignanciesThe International Journal of Biochemistry & Cell Biology, 1999
- Detection of the proto-oncogene eIF4E in surgical margins may predict recurrence in head and neck cancerOncogene, 1997
- Translational regulation of vascular permeability factor by eukaryotic initiation factor 4E: Implications for tumor angiogenesisInternational Journal of Cancer, 1996
- The proto‐oncogene/translation factor eIF4E: A survey of its expression in breast carcinomasInternational Journal of Cancer, 1995
- Decreasing the level of translation initiation factor 4E with antisense rna causes reversal of ras‐mediated transformation and tumorigenesis of cloned rat embryo fibroblastsInternational Journal of Cancer, 1993
- Expression of antisense RNA against initiation factor eIF-4E mRNA in HeLa cells results in lengthened cell division times, diminished translation rates, and reduced levels of both eIF-4E and the p220 component of eIF-4F.Molecular and Cellular Biology, 1991
- Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' capNature, 1990