Dose-rate effects in biomembranes.

Abstract
Mice were whole body X-irradiated with different doses and different dose-rates. Directly hereafter lipid peroxidation capacity of the liver membranes was measured. The lag phase prior to rapid peroxidation was clearly shortened at higher doses and also at lower dose rates when the same dose was applied. The dose-rate effects were found at dose-rates less than 1-1.5 Gy/min. With a dose-rate as low as 0.2 Gy/min radiation effects on the liver with doses of 7.5 Gy could be found. The significance of these findings for cell survival after irradiation is discussed.

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