Mediation of Diurnal Fluctuations in Pain Sensitivity in the Rat by Food Intake Patterns: Reversal by Naloxone
- 10 October 1980
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 210 (4466) , 210-211
- https://doi.org/10.1126/science.7191143
Abstract
Rats maintained on a 12-hour light-dark cycle were tested for pain sensitivity after being deprived of food during either the dark or the light phase of the cycle. Diurnal fluctuations in pain sensitivity were observed. The fluctuations followed food intake patterns rather than a natural circadian rhythm, with food deprivation producing a decrease in pain sensitivity. The analgesic response produced by this mild food deprivation was strongly attenuated by naloxone or feeding, suggesting that endogenous opioid systems may be related to patterns of food intake.Keywords
This publication has 22 references indexed in Scilit:
- Neonatal administration of β-endorphin produces “chronic” insensitivity to thermal stimuliLife Sciences, 1979
- Melatonin and corticosterone regulation: Feeding time or the light:Dark cycle?Life Sciences, 1979
- Effect of naloxone on analgesia induced by food deprivationLife Sciences, 1979
- Diurnal rhythms in nociceptive thresholds of ratsPhysiology & Behavior, 1979
- β-endorphin is a kidney trophic hormoneLife Sciences, 1979
- Diurnal differences in opioid peptide levels correlated with nociceptive sensitivityLife Sciences, 1979
- Suppression of food intake and body weight gain by naloxone in ratsLife Sciences, 1979
- In vitro lipolytic activity of porcine β‐endorphin not mediated by an opiate receptorFEBS Letters, 1979
- Suppression of appetitive behavior in the rat by naloxone: Lack of effect of prior morphine dependenceLife Sciences, 1979
- Light-dark rhythms in rat eating and drinking behaviorPhysiology & Behavior, 1971