Some Observations on the Use of Alum Precipitated Diphtheria Toxoid

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Abstract
To test the theory that the activity of alum precipitated toxoid lies in the slow rate of absorption of the comparatively insoluble precipitate, the author dissected the nodules which persist at the site of injection in guinea pigs, and reinjected them into pigs in which the absence of antitoxin had been demonstrated. The nodules, removed from 2 to 4 pigs each week up to the 7th, were ground in a mortar with salt solution and injected into 2 test pigs. The test pigs were bled after 6 weeks, the serum of each pair pooled and tested for antitoxin. Antitoxin was present in the serum of all, those reinjected at the 7th week showing 1/5 unit per cc. Localization of virus was observed around the indurated nodule in individ-uals vaccinated for smallpox 11 days after the injection of precipitated toxoid. 9 out of 11 subjects vaccinated 21 days after the injection of toxoid showed normal vaccinia and 2 indicated a tendency of the virus to localize at the site of the toxoid injection.

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