Antigenic Differences Among Strains of Newcastle Disease Virus.

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Abstract
Immune sera were prepd. for strains of Newcastle disease virus isolated from many localities in the U. S., Canada and Mexico and from a few places in the Old World. Results in 17 heterologous combinations of Newcastle disease virus and antiserum, tested by the serum neutralization procedure, are reported. Of these combinations, 13 exhibited a probably significant difference of greater than 1 log between the neutralization of the homologous and the heterologous virus by prepd. antiserum. A very significant difference of 5 logs was observed between 2 strains. The study of antigenic diversity of strains of Newcastle disease virus, while still in preliminary stages, revealed differences of diagnostic importance and raised a question of the feasibility of using a vaccine prepd. from one antigen in all situations.

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