General Resorption of Intra Vesically Instilled 5-fluorouracil

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Abstract
To evaluate the resorption of intravesically instilled 5-fluorouracil [an antineoplastic drug], a single dose of 250 or 1000 mg was injected into the empty bladder for 3 h in 17 patients [with bladder tumors]. The concentration of 5-fluorouracil in serum during instillation was recorded. A microbiologic agar plate method was used for the assay. No measurable 5-fluorouracil concentrations were recorded in the systemic blood of patients with undamaged bladder mucosa, and low levels (< 100 ng/ml serum) of 5-fluorouracil were found in the systemic circulation of patients with mucosal lesions.