Spectrofluorimetric Determination of Zinc with 1,2,4-trihydroxyanthraquinone in Pharmaceutical Preparations

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Abstract
A new method for the spectrofluorimetric determination of zinc with 1,2,4-Trihydroxyanthraquinone in a 80:20 (v/v) ethylene glycol/water medium and at an apparent pH 8.87 provided by an ammonia/ammonium chloride buffer (pH = 9.30) is proposed. The method allows the determination of zinc over the range 50–500 ng/ml and features a detection limit of 2.31 ng/ml. The influence of various chemical and physical variables affecting the reaction was evaluated and the effects of potential major interferences with the method are commented on. The proposed method has been successfully applied to the determination of zinc in several pharmaceutical preparations.