NEUROTOXICITY OF ADRIAMYCIN IN RATS - A LOW-DOSE EFFECT

  • 1 January 1980
    • journal article
    • research article
    • Vol. 64  (2-3) , 257-261
Abstract
A neurotoxic effect of adriamycin [an antineoplastic drug] in rats was noted following a single i.v. dose level of 5 mg/kg of body weight (35 mg/m2 of body surface area). The changes studied in the dorsal root ganglia were qualitatively similar to those previously reported at a higher dose level. The early changes involved neuronal nuclei and included focal regions of clearing and altered staining of chromatin. Necrosis of many affected neurons followed; the evolution of this lesion was slower than that seen in previous studies using the higher dose of the drug.

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