Some New Aspects of the Relationship of Chemical Structure to Biological Activity
- 29 December 1944
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 100 (2609) , 579-583
- https://doi.org/10.1126/science.100.2609.579
Abstract
Sulfonic acids prevented bacterial growth by causing specific deficencies of vits. or metabolites. Certain compds. related to vits. or other metabolites caused specific deficiency diseases in animals. Microbial growth was inhibited with analogs of various metabolites and the effect was reversed with increased amts. of the metabolite concerned. Compounds which caused some anticipated pharma-col. signs have been predicted and synthesized. It remains to produce compounds having useful therapeutic action. Metabolite structure has been modified in many ways to produce inhibitory compounds.This publication has 24 references indexed in Scilit:
- Thiamine Inactivation by the Chastek-Paralysis Factor. Inhibition1 of Thiamine InactivationJournal of the American Chemical Society, 1944
- The Anti-Biotin Effect of DesthiobiotinScience, 1944
- SELECTIVE REVERSIBLE INHIBITION OF MICROBIAL GROWTH WITH PYRITHIAMINEThe Journal of Experimental Medicine, 1943
- PRODUCTION OF A SCURVY-LIKE CONDITION BY FEEDING OF A COMPOUND STRUCTURALLY RELATED TO ASCORBIC ACIDThe Journal of Experimental Medicine, 1943
- Über einen Antagonisten des LactoflavinsBerichte der deutschen chemischen Gesellschaft (A and B Series), 1943
- Growth Effects of α-Methyl Homologs of Pantothenic Acid and β-AlanineJournal of the American Chemical Society, 1943
- p-Aminophenylketone als Antagonisten der p-AminobenzoesäureHoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1942
- Synthese des [α,γ‐Dioxy‐β.β‐dimethyl‐butyryl]‐taurins, eines spezifischen Hemmstoffes für MilchsäurebakterienBerichte der deutschen chemischen Gesellschaft (A and B Series), 1941
- 18. Amino-sulphonic acid analogues of natural amino-carboxylic acidsJournal of the Chemical Society, 1941
- Para-Amino Benzoic Acid as a Bacterial Growth FactorNature, 1940