Calcium‐activated calcium permeability in parathyroid cells
- 1 September 1986
- journal article
- Published by Wiley in FEBS Letters
- Vol. 205 (1) , 132-136
- https://doi.org/10.1016/0014-5793(86)80880-8
Abstract
The Ca2+ receptor mechanism of the parathyroid cell was studied using La3+ as a probe. La3+ was found to bind to the cell surface without further penetration. Measurements of 45Ca fluxes and the cytoplasmic Ca2+ concentration (Cai 2+) revealed a stimulatory component in the action of La3+ on Ca2+ permeability resulting in a rise in Cai 2+ These effects mimicked those obtained when raising the extracellular Ca2+ concentration from 0.5 to 3.0 mM, but the actions of La3+ and Ca2+ were not additive. The results suggest the existence of a novel Ca2+ permeability physiologically activated by binding of Ca2+ to an external receptor.Keywords
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