Synthesis of Chiral 3-Substituted Phthalides via Rhodium(I)-catalyzed Crossed Alkyne Cyclotrimerisation
- 21 October 2002
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 2002 (11) , 1855-1859
- https://doi.org/10.1055/s-2002-34883
Abstract
3-Substituted phthalides were synthesized for the first time by crossed alkyne cyclotrimerisations with Wilkinson’s catalyst. Esterification of propiolic acids with chiral propargylic alcohols by either the DCC/DMAP or the Mitsunobu method allows the synthesis of either enantiomeric form of diyne esters, that are used in crossed alkyne cyclotrimerisations with acetylene to provide 3-substituted phthalides in both enantiomeric forms.Keywords
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