AUTONOMOUS OVARIAN HYPERFUNCTION FOLLOWED BY GONADOTROPHIN‐DEPENDENT PUBERTY IN McCUNE‐ALBRIGHT SYNDROME

Abstract
A 5-year-old girl with the McCune-Albright syndrome presented with precocious puberty secondary to autonomously functioning ovarian cysts, followed by true central puberty. Progression from gonadotrophin-independent to gonadotrophin-dependent precocious puberty may occur from elevated sex steroid levels leading to the early maturation of the hypothalamic-pituitary axis.