Inhibition of adenosine deaminase and of platelet aggregation by 2-azidoadenosine, a photolysable analogue of adenosine

Open Access

18 May 1976

journal article
Published by The Royal Society in Proceedings of the Royal Society of London. B. Biological Sciences

Vol. 193 (1112) , 307-311
https://doi.org/10.1098/rspb.1976.0048

Abstract

Aggregation of human blood platelets induced by ADP was strongly inhibited by 2-azidoadenosine, a photolysable analogue of adenosine. The deamination of adenosine by adenosine deaminase (E.C. 3.5.4.4) was competitively inhibited by 2-azidoadenosine. In the presence of 2-azidoadenosine the enzyme was inactivated by u.v. radiation. The inactivation was diminished in the presence of a protein scavanger.

Keywords

This publication has 5 references indexed in Scilit:

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