AGING IN AN ADULT INSECT HEART

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Abstract
The rate of beating in semi-isolated preparations of the heart of adult males and females of Acheta domesticus (L.) increased with age up to 6 weeks after emergence, after which it declined during the last few weeks of life. The hearts of young adults tended to be accelerated with acetylcholine, serotonin, and dopamine, whereas the hearts of older adults tended to be inhibited by the same concentration of these substances. On the basis of these results, aging of the heart might be considered as a process of adaptation to the forces controlling the heart. The varying effect of drugs with age, a relationship not notice before, limits the usefulness of pharmacological studies with an insect heart which presupposes a similar effect of a drug on all hearts.

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