A New and Practical Procedure for the Bruylants Reaction. Zinc-Mediated Synthesis of Tertiary Homoallylamines and β-Aminoesters
- 19 September 2003
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 2003 (12) , 1778-1782
- https://doi.org/10.1055/s-2003-41471
Abstract
N,N-Disubstituted α-aminonitriles undergo Bruylants reaction under Barbier and Reformatsky conditions with activated halides, in the presence of zinc and 10 mol% HOAc. The high yields and the simple operational conditions make this reaction an appealing approach to N,N-disubstituted homoallylamines and β-aminoesters.Keywords
This publication has 0 references indexed in Scilit: