THE MECHANISM OF THE INHIBITORY ACTION OF VASODILATOR NERVES

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Abstract
The responses of the blood vessels of a perfused frog leg were recorded by a sensitive flowmeter, indicating the rate of flow of the perfusion fluid. Excitatory and inhibitory effects were produced by stimulating respectively the sympathetic trunk and the dorsal roots. Inhibitory stimulation causes dilatation, if the vessels are in a state of tonic constriction. Furthermore the inhibitory impulses can completely abolish the response to sympathetic stimulation. The inhibition is complete at low frequencies (about 1 per sec.) of constrictor impulses, but becomes relatively smaller at higher frequencies. An explanation of this relation can be given on the basis of the humoral mediation of impulses.

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