Mechanism of the Toxic Action of Germicides on Whole Blood Measured by the Loss of Phagocytic Activity of Leucocytes

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Abstract
Summary and Conclusions: The thermolabile component of complement in guinea pig blood which accelerates phagocytosis is an essential factor in the proposed method for determining the toxicity of germicides. The thermostabile opsonin appears to be responsible for the greater resistance of human blood to the action of germicidal substances. The expected normal variation in the opsonic activity of guinea pig complement had no effect on the “toxic endpoint” of a germicide when tested by the proposed method. The toxic effect of germicides when tested on human or guinea pig blood as a tissue appears to be directed against the humoral in contrast to the cellular elements.

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