Ketosis in the hypophysectomized rat

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Abstract
Hypophysectomized [female] rats excreted only traces of acetone bodies in the urine when fed on a diet for as long as a wk., nor did they show any increase in ketonuria after the subcut. inj. of adrenaline. Control animals showed a variable but definite ketonuria, which was increased by the inj. of adrenaline. At the end of the period of fat-feeding, blood acetone bodies were higher in the hypophysectomized than in the control rats and were above the normal threshold level. The absence of ketonuria in the hypophysectomized rats is apparently due to an increase in the renal threshold for acetone bodies after the removal of the pituitary.