Serum Aluminum Levels and Erythrocyte Dihydropteridine Reductase Activity in Patients on Hemodialysis
- 9 July 1987
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 317 (2) , 80-84
- https://doi.org/10.1056/nejm198707093170204
Abstract
Aluminum intoxication due to aluminum-containing antacids or dialysate can cause encephalopathy in patients undergoing hemodialysis, but the biochemical mechanism has not been defined. The enzyme dihydropteridine reductase (DHPR) is essential for the maintenance of normal brain concentrations of tetrahydrobiopterin, which is itself required for the synthesis of specific neurotransmitters. This enzyme is also present in erythrocytes.This publication has 33 references indexed in Scilit:
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