The General Anesthetic Propofol Excites Nociceptors by Activating TRPV1 and TRPA1 Rather than GABAA Receptors
Open Access
- 1 November 2010
- journal article
- Published by Elsevier in Journal of Biological Chemistry
- Vol. 285 (45) , 34781-34792
- https://doi.org/10.1074/jbc.m110.143958
Abstract
No abstract availableKeywords
This publication has 63 references indexed in Scilit:
- GABA Increases Electrical Excitability in a Subset of Human Unmyelinated Peripheral AxonsPLOS ONE, 2010
- Oxidative challenges sensitize the capsaicin receptor by covalent cysteine modificationProceedings of the National Academy of Sciences, 2009
- The Nociceptor Ion Channel TRPA1 Is Potentiated and Inactivated by Permeating Calcium IonsJournal of Biological Chemistry, 2008
- A-Type GABA Receptor as a Central Target of TRPM8 Agonist MentholPLOS ONE, 2008
- Identification of Transmembrane Domain 5 as a Critical Molecular Determinant of Menthol Sensitivity in Mammalian TRPA1 ChannelsJournal of Neuroscience, 2008
- General anesthetics activate a nociceptive ion channel to enhance pain and inflammationProceedings of the National Academy of Sciences, 2008
- The vanilloid receptor TRPV1 is activated and sensitized by local anesthetics in rodent sensory neuronsJournal of Clinical Investigation, 2008
- TRPA1 mediates formalin-induced painProceedings of the National Academy of Sciences, 2007
- TRP channel activation by reversible covalent modificationProceedings of the National Academy of Sciences, 2006
- Ethical guidelines for investigations of experimental pain in conscious animalsPAIN®, 1983