Conjunctival biopsy in Sjögren's syndrome: correlations between histological and immunohistochemical features

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Abstract
We have examined conjunctival biopsies from nine primary and two secondary cases of Sjogren''s syndrome. In all cases histopathological examination revealed metapliasia of the conjunctival epithelium associated with a reduced number of goblet cells and a polymorphic inflammatory cell infiltrate of the stroma. Using monoclonal antibodies with texture analysis of stained preparations we have shown that in all cases the lymphocytic infiltrative was predominately T-cell but with substantial numbers of IgA and IgG secretory B-cells in three cases. The number of Langerhans cells present was reduced in biopsies showing the most marked degree of epithelial metaplasia.