The Rat Adrenal Medulla. II. Proliferative Lesions
- 1 January 1988
- journal article
- research article
- Published by SAGE Publications in Journal of the American College of Toxicology
- Vol. 7 (1) , 23-44
- https://doi.org/10.3109/10915818809078701
Abstract
Many strains of rats develop spontaneous or drug-induced adrenal medullary proliferative lesions. However, there is often ambiguity about whether the changes observed are hyperplastic or neoplastic and if the term “pheochromocytoma” is appropriate for the lesion in rodents. Various considerations are presented, and the evolution and morphology of the changes are discussed. The lesions are of practical interest because they have at times impeded drug licensing applications.Keywords
This publication has 41 references indexed in Scilit:
- Enzootic and Epizootic Adrenal Medullary Proliferative Disease of Rats: Influence of Dietary Factors which Affect Calcium AbsorptionHuman Toxicology, 1985
- Damage to Hypothalamic Dopaminergic Neurons Is Associated with Development of Prolactin-Secreting Pituitary TumorsScience, 1982
- Raben Lecture 1980: A Tale of Stature*Endocrine Reviews, 1980
- Neoplastic and nonneoplastic lesions in aging osborne-mendel ratsToxicology and Applied Pharmacology, 1980
- Ganglioneuromas in the Adrenal Medulla of F344 RatsVeterinary Pathology, 1980
- Circulating and Urinary Catecholamines in PheochromocytomaNew England Journal of Medicine, 1979
- Neoplastic and nonneoplastic lesions in aging F344 ratsToxicology and Applied Pharmacology, 1979
- Two Populations of Microvesicles in the SGC (Small Granule Chromaffin) Cells of the Mouse Adrenal MedullaArchivum histologicum japonicum, 1977
- Mutation and Cancer: Statistical Study of RetinoblastomaProceedings of the National Academy of Sciences, 1971
- Increased Tyrosine Hydroxylase Activity after Drug-induced Alteration of Sympathetic TransmissionNature, 1969