Regulation of Antigen-Specific CD8 + T Cell Homeostasis by Perforin and Interferon-γ
Top Cited Papers
- 17 November 2000
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 290 (5495) , 1354-1357
- https://doi.org/10.1126/science.290.5495.1354
Abstract
T cell memory depends on factors that regulate expansion and death of these cells after antigenic stimulation. Mice deficient in perforin and interferon-γ (IFN-γ) exhibited increased expansion, altered immunodominance, and decreased death of antigen-specific CD8+ T cells after infection with an attenuated strain ofListeria monocytogenes, which was cleared from these mice. Expansion of CD8+ T cells was controlled by perforin, whereas IFN-γ regulated immunodominance and the death phase. Thus, perforin and IFN-γ regulate distinct elements of CD8+ T cell homeostasis independently of their role as antimicrobial effector molecules.Keywords
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