Short synthesis of the optically active E-ring portion of (S)-camptothecin
- 23 October 2001
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 22,p. 2903-2905
- https://doi.org/10.1039/b109071m
Abstract
(5S)-5-Benzyloxy-5-ethyl-6-oxo-5,6-dihydro-2H-pyran-3-carboxylic acid, the protected E-ring moiety of (S)-camptothecin, has been rapidly prepared in enantiomerically enriched form (98% ee) through enolate conjugate addition to a β-bromo methacrylate derivative, followed by enzymatic resolution with PLE.Keywords
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