Effects of Feeding Thiouracil on Thyroid Glands of Rats

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Abstract
Inbred rats of the Fischer, A × C, and Marshall strains were fed thiouracil in a moderately low-iodine diet for various time intervals. The cells of the thyroid glands of these rats were arranged in several histologic patterns in addition to diffuse hyperplasia. These papillary and solid-cell patterns were localized in nodules or foci. There appeared to be strain differences in the frequency and type of focal change. Peculiar bodies with concentric laminations were observed frequently in the lumen of follicles in 2 strains. In many respects the results resembled those of Axelrad and Leblond obtained by feeding Wistar rats a low-iodine diet.