Preparation and evaluation of sustained release tablets prepared with .ALPHA.-starch.

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Abstract
A compressed tablet prepared from .alpha.-starch adsorbed water from the release medium and formed a gel, starting from the tablet surface. Theophylline was released slowly through the gelled layer. Release rates of theophylline from tablets prepared with .alpha.-starches from different sources were different. Release rates of theophylline from the tablets were faster in an acidic medium than in a neutral medium. The release rate of theophylline was faster in a medium containing .alpha.-amylase than in a medium without the enzyme. Salivary levels were lower but were sustained for longer following oral administration of an .alpha.-starch tablet than those after administration of a rapidly dissolving tablet in humans.

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