EVIDENCE, FROM CROSSTRANSFUSION EXPERIMENTS, THAT NO TOXIC FACTOR IS PRESENT IN ISCHEMIC COMPRESSION SHOCK CAPABLE OF INDUCING A SHOCK STATE IN NORMAL DOGS

Publisher Website
Google Scholar
Abstract
In 12 expts. both hind legs of a dog were traumatized by compressing them with rubber tubing wrapped in a continuous spiral from the ankle to the groin. This procedure rendered the legs completely ischemic. This dog, designated as the traumatized (shock) dog, was then crosstransfused with a test dog beginning 30-45 mins. before release of the rubber tubes and continuing usually until the death of the traumatized dog. In the various expts., the crosstransfusion was maintained for 1.2-4.75 hrs. after release of the compression and amounted to 1.6-35.4 1. The crosstransfusion was carried out by means of a stromuhr which assured us that the test dog neither lost to nor gained blood vol. from the traumatized dog. In 6 expts., all the blood returning from the traumatized extremities by way of the vena cava passed through the test dog before returning to the traumatized dog. All traumatized dogs died within 1.2-5.1 hrs. after release of the compression. Eight of the test dogs survived indefinitely. The remaining 4 maintained their arterial pressure throughout the crosstransfusion and for several hrs. thereafter. Their ultimate death can, it is believed, be explained on technical grounds. These expts. demonstrate that no toxic factor appears in the circulation in this form of trauma which can initiate shock. They render unlikely but do not rule out the possibility that a hypothetical factor might be present which could play a contributory role in a traumatized animal in the presence of a circulation impaired by severe loss of plasma and/ or blood in the traumatized tissues.

This publication has 20 references indexed in Scilit: